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Effects of electrical stimulation of lateral hypothalamic area on gastric ischemia-reperfusion injury in rats

Zhou Xiuping, Zhang Jianfu, Yan Changdong, Zhang Yongmei

Department of Physiology,Xuzhou Medical College.Xuzhou 221002,Jiangsu

Abstract

Electrical stimulation of LHA could aggravate GI-RI in an intensity-dependent manner by using 0.2, 0.4 or 0.6 mA current respectively. Microinjection of L-glutamic acid into LHA resulted in a similar effect to that of electrical stimulation of LHA on GI-RI. After electrolytic lesion of bilateral LHA, the are of gastric mucosal injury induced by gastric ischemia-reperfusion (GI-R) was smaller than that by electrical stimulation of LHA plus GI-R. Dorsal vagal complex (DVC) lesion or vagotomy could eliminate the effect of electrical stimulation of LHA on GI-RI. Electrical stimulation of LHA increased the content of malondialdehyde (MDA) but decreased the activity of superoxide dismutase (SOD) of ischemia-reperfusion (I-R) gastric mucosa. Electrical stimulation of LHA plus gastric I-R increased gastric juice volume and total acid output, but there were no significant changes in acidity, pepsin activity and gastric barrier mucus.

Key words: Hypothalamic area;Lateral;Gastric;Ischemia;Reperfusion injury;Solitary nucleus;Vagal motor nucleus;Vagus nerve;Malondialdehyde;Superoxide dismutase

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Citing This Article：

Zhou Xiuping, Zhang Jianfu, Yan Changdong, Zhang Yongmei. Effects of electrical stimulation of lateral hypothalamic area on gastric ischemia-reperfusion injury in rats. Acta Physiol Sin 2002; 54 (5): (in Chinese with English abstract).