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Heterogeneity of action potential and ion currents in the left ventricular myocytes of the rabbit

Li Yang, Ma Jie, Xiao Jianmin, Liu Nian, Niu Huiyan, Lu Zaiying

Department of Cardiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology.Wuhan 430030,Hubei

Abstract

The results showed that the action potential and the ion currents in the three layers were significantly different. M cells had a more pronounced spike-and-dome configuration, with a significantly larger phase 1 magnitude and plateau voltage. Action potential duration (APD) in M cells was longer than that in Epi or Endo cells I_(Ca,L) and I_(to) in M cells were higher than those ofo Epi and Endo. On the contrary, I_(K,s) in M cells was the minimum compared with those in the three LV walls. The differences in ion currents may well explain the heterogeneity of action potentials in M layers of the rabbit heart.

Key words: Heterogeneity;Free wall of left ventricular myocytes;Action potentials;Ion channels;Rabbit

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Citing This Article：

Li Yang, Ma Jie, Xiao Jianmin, Liu Nian, Niu Huiyan, Lu Zaiying. Heterogeneity of action potential and ion currents in the left ventricular myocytes of the rabbit. Acta Physiol Sin 2002; 54 (5): (in Chinese with English abstract).