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Effect of SO_(2) derivatives on sodium currents in acutely isolated rat hippocampal CA1 neurons

Meng Ziqiang, Sang Nan

Institute of Environmental Medicine and Toxicology,Shanxi University.Taiyuan 030006,Shanxi

Abstract

The results indicated that SO_(2) derivatives caused a dose-dependent and voltage-dependent increase in the voltage-activated Na~(+) currents. The amplitudes of Na~(+) currents were increased by 50.59±19.08% and 82.06±18.51% (n=15) by SO_(2) derivatives at 10 and 100 #mu#mol/L, respectively. The action was frequency-independent. The results also showed that SO_(2) derivatives did not affect the activation process, but changed the inactivation process significantly. Before and after application of 10 #mu#mol/L SO_(2) derivatives, the half-inactivation voltage was -69.71±4.67 and -53.27±4.95 mV (n=10, P<0.01), respectively, but the slope factor was not changed.

Key words: Hippocampus;Neurons;Patch-clamp techniques;Sulfur dioxide;Sodium channels

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Citing This Article：

Meng Ziqiang, Sang Nan. Effect of SO_(2) derivatives on sodium currents in acutely isolated rat hippocampal CA1 neurons. Acta Physiol Sin 2002; 54 (3): (in Chinese with English abstract).