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The expression of neuronal nitric oxide synthase in caudal medulla of two-kidney one clip Goldblatt hypertension rat

Wang Jing, Chen Zhijiang, Luo Canqiao, Pan Jingyun

Department of Physiology,Fujian Medical University.Fuzhou 350004,Fujian；China；Departments of Pathology,Sun Yat-Sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

The results showed that: (1)only a few neuronal nitric oxide synthase (nNOS) positive neurones were found in caudal medulla, including the depressor area of the ventral surface of medulla oblongata (VSMd) and the caudal pressor area (CPA) of the sham operated animals. The number of nNOS positive neurons in caudal medulla was significantly increased in 2K1C Goldblatt hypertension rats at 4 and 7 weeks. (2)The number of nNOS positive neurons in VSMd and CPA were 2K1C+Arg>2K1C>2K1C+NAME>sham. (3)L-Arg enhanced the expression of nNOS whereas L-NAME inhibited the expression of nNOS in caudal medulla. (4)The character of nNOS expression was similar in Goldblatt hypertension rats at 4 weeks with that of the rats at 7 weeks.

Key words: Depressor area of the ventral surface of medulla oblongata;Caudal pressor area;Neuronal nitric oxide synthase;L-arginine;N(G)-nitro-L-arginine methyl ester

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Citing This Article：

Wang Jing, Chen Zhijiang, Luo Canqiao, Pan Jingyun. The expression of neuronal nitric oxide synthase in caudal medulla of two-kidney one clip Goldblatt hypertension rat. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).