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Inhibitory effect of cholecystokinin-octapeptide on production of cytokines in the lung of endotoxic shock rats

Meng Aihong, Ling Yiling, Zhao Xiaoyun, Zhang Junlan, Wang Qiuhong

Department of Pathophysiology,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The results showed that CCK-8 alleviated LPS-induced decreased in MAP of rats; compared with the control, LPS elevated the levels of TNF-#alpha#, IL-1#beta# and IL-6 in serum and lung significantly, while CCK-8 significantly inhibited the LPS-induced increases in TNF-#alpha#, IL-1#beta# and IL-6 in serum and lung. The activation of p38 MAPK in the lung of ES rats was enhanced by CCK-8 pretreatment.

Key words: Cholecystokininr octapeptide;Endotoxin;Cytokine;Lung;p38 mitogen-activated protein kinase

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Citing This Article：

Meng Aihong, Ling Yiling, Zhao Xiaoyun, Zhang Junlan, Wang Qiuhong. Inhibitory effect of cholecystokinin-octapeptide on production of cytokines in the lung of endotoxic shock rats. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).