ISSN 0371-0874, CN 31-1352/Q

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Influence of regulatory peptides on the secretion of interleukins from bronchial epithelial cells of the rabbit

Tan Yurong, Qin Xiaoqun, Guan Chaxiang, Zhang Changqing, Xiang Yang, Ren Yanhong

Department of Physiology,Xiangya Medical College,Central South University.Changsha 410078,Hunan

Abstract

The results of the experiments showed that VIP exerted an inhibitory effect on the secretion of IL-1 and IL-8 from unstimulated and O_(3)-stressed BECs, VIP also decreased the secretion of IL-5 from O_(3)-stressed BECs; EGF promoted secretion of IL-1 and IL-8 from unstimulated BECs, but decreased the secretion of ILs from O_(3)-stressed BECs; ET-1 and CGRP enhanced the secretion of IL-1, IL-5, and IL-8 from unstimlated BECs, CGRP also increased the secretion of ILs from O_(3)-stressed BECs.

Key words: Regulatory peptides;Secretion;Bronchial epithelial cells

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Citing This Article:

Tan Yurong, Qin Xiaoqun, Guan Chaxiang, Zhang Changqing, Xiang Yang, Ren Yanhong. Influence of regulatory peptides on the secretion of interleukins from bronchial epithelial cells of the rabbit. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).