Issue Archive

Role of platelet-derived growth factor receptor-mediated signal transduction in myocardial hypertrophy of spontaneously hypertensive rats

Liu Jie, Bai Hua, Xing Dongqi, Sun Yinping, Wu Liling

Department of Physiology and Pathophysiology,Peking University Health Science Center.Beijing 100083；China；Department of Pathophysiology,Xinxiang Medical College.Xinxiang 453003,Henan

Abstract

The role of platelet-derived growth factor (PDGF) receptor-mediated signal transduction in myocardial hypertrophy of spontaneously hypertensive rats (SHR) was investigated. The protein expressions of PDGF #beta# receptor and extracellular signal-regulated kinase 1/2 (ERK 1/2) and the level of phosphorylated ERK 1/2 (pERK 1/2) in cardiac tissues from 4- and 12-week-old SHR and their age-matched normotensive control Wistar-Kyoto rats (WKY) were examined by Western blot analysis.

Key words: Platelet-derived growth factor receptor;Signal transduction;Myocardial hypertrophy;Spontaneously hypertensive rats

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Liu Jie, Bai Hua, Xing Dongqi, Sun Yinping, Wu Liling. Role of platelet-derived growth factor receptor-mediated signal transduction in myocardial hypertrophy of spontaneously hypertensive rats. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).