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Protective effect of low concentration endothelin-1 on the reactive oxygen-induced inhibition of pulmonary surfactant lipid synthesis

Luo Ziqiang, Feng Dandan, Zhou Fuwen, Zhang Changqing, Qin Xiaoqun, Sun Xiuhong

Department of Physiology,Xiangya Medical College,Central Southern University.Changsha 410078,Hunan

Abstract

These results suggest that ET-1 at low concentration can protect the microsomal CCT activity and reduce the inhibition of PS lipid synthesis induced by oxidant lung injury. The protective mechanism of ET-1 is not relative to the pulmonary endogenous antioxidant defense system.

Key words: Endothelin-1;Pulmonary surfactant;CTP;Phosphoiylcholine cytidylyltransferase

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Citing This Article：

Luo Ziqiang, Feng Dandan, Zhou Fuwen, Zhang Changqing, Qin Xiaoqun, Sun Xiuhong. Protective effect of low concentration endothelin-1 on the reactive oxygen-induced inhibition of pulmonary surfactant lipid synthesis. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).