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ATP-sensitive potassium channels and endogenous adenosine are involved in spinal antinociception produced by locus coeruleus stimulation

Han Baofen, Zhang Ce, Qi Jinshun, Qiao Jiantian

Department of Neurobiology,Shanxi Medical University.Taiyuan 030001,Shanxi

Abstract

These results suggest that: (1)K~(+)_(ATP) channels and endogenous adenosine may be involved in the mediation of spinal antinociception induced by descending adrenergic fibers originating from the LC; and (2) the opening of K~(+)_(ATP) channels precedes the release of adenosine in the cascade of mediation.

Key words: Locus coeruleus stimulation;Parafascicular nociceptive neurons;Intrathecal injection;ATP-sensitive potassium channel;Adenosine

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Citing This Article：

Han Baofen, Zhang Ce, Qi Jinshun, Qiao Jiantian. ATP-sensitive potassium channels and endogenous adenosine are involved in spinal antinociception produced by locus coeruleus stimulation. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).