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Protective effects of paraventricular nucleus stimulation and vasopressin on gastric ischemia-reperfusion injury in rats

Zhang Jianfu, Zhang Yongmei, Yan Changdong, Zhou Xiuping, Qi Youjian

Department of Physiology,Xuzhou Medical College.Xuzhou 221002,Jiangsu；China

Abstract

These results suggest that the PVN and AVP participate in the regulation of GI-RI and play an important role in protection against GI-RI. This protective effect of PVN on GI-RI might be mediated by activation of AVP-ergic neurons in the PVN, which release AVP from the descending projection fibers and activate the AVP-V_(1) receptors on the NTS neurons. The vagus and sympathetic nerves are involved in the efferent pathway exerting their effects on GI-RI. Hypophysis does not seem to be involved in the protective effect of PVN stimulation.

Key words: Paraventricular nucleus(PVN);Arginine-vasopressin(AVP);Nucleus tractus solitarius(NTS);Hypophysis;Gastric ischemia-reperfusion injury(GI-RI)

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Citing This Article：

Zhang Jianfu, Zhang Yongmei, Yan Changdong, Zhou Xiuping, Qi Youjian. Protective effects of paraventricular nucleus stimulation and vasopressin on gastric ischemia-reperfusion injury in rats. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).