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Effects of rhIL-6 on Bcl-2 and Bax expression and apoptosis after anoxia-reoxygenation in cultured rat hippocampal neurons

Ding Aishi, Wang Fuzhuang, Wu Liying, Fan Ming

Department of Neurobiology,Institute of Basic Medical Sciences,Academy of Military Medical Sciences.Beijing 100850

Abstract

The results showed that in cultured hippocampal neurons the Bcl-1 expression decreased while Bax expression and the percentage of apoptotic neurons increased after anoxia-reoxygenation compared with those before anoxia. In comparison with the control, after anoxia-reoxygenation the Bcl-2 expression in hippocampal neurons was higher than that in rhIL-6 group; however, the Bax expression and the precentage of the apoptosis were decreased in rhIL-6 group. It is suggested that rhIL-6 may play a role in protecting neurons from the damage induced by anoxia-reoxygenation.

Key words: Recombinant human interleukin-6;Hippocampal neurons;Anoxia-reoxygenation;Bcl-2;Bax;Apoptosis

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Citing This Article：

Ding Aishi, Wang Fuzhuang, Wu Liying, Fan Ming. Effects of rhIL-6 on Bcl-2 and Bax expression and apoptosis after anoxia-reoxygenation in cultured rat hippocampal neurons. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).