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Increased resistance against oxidant-induced injury in the rat vascular smooth muscle cells transfected with human heme oxygenase-1 gene

Zhang Min, An Wei, Du Haijun, Chen Li, Zhang Baohui

Institute of Sports Medicine,The Third Hospital,Peking University.Beijing 100083；China

Abstract

The heme oxygenase-1 (HO-1), a rate-limiting enzyme in heme metabolism, has been recently defined as a novel stress-stimulated protein, since the intracellular expression of HO-1 in response to various stimuli as oxidation, ischemia and endotoxin injury has been proved to be able to protect the cells from damage.

Key words: Heme oxygenase;Retroviral vector;Active oxygen;Vascular smooth muscle cells

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Citing This Article：

Zhang Min, An Wei, Du Haijun, Chen Li, Zhang Baohui. Increased resistance against oxidant-induced injury in the rat vascular smooth muscle cells transfected with human heme oxygenase-1 gene. Acta Physiol Sin 2002; 54 (1): (in Chinese with English abstract).