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Expression of intercellular adhesion molecule-1 in different organs of the mice with endotoxic shock induced by lipopolysaccharide

Yan Wensheng, Kan Wenhong, Huang Qiaobing, Jiang Yong, Wang Shiwen, Zhao Kesen

Key Laboratory of Shock and Microcirculation of PLA,The First Military Medical University.Guangzhou 510515,Guangdong；China

Abstract

Results highlight that LPS can up-regulate ICAM-1 protein and mRNA expression in different tissues of the mice with endotoxic shock. The difference in ICAM-1 expression among the organs may lead to different sensitivity of organ damage in endotoxic shock. This suggests that inhibition of ICAM-1 expression may be a useful principle for prevention and treatment of endotoxic shock.

Key words: Endotoxic shock;Lipopolysaccharide;Intercellular adhesion molecule-1

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Citing This Article：

Yan Wensheng, Kan Wenhong, Huang Qiaobing, Jiang Yong, Wang Shiwen, Zhao Kesen. Expression of intercellular adhesion molecule-1 in different organs of the mice with endotoxic shock induced by lipopolysaccharide. Acta Physiol Sin 2002; 54 (1): (in Chinese with English abstract).