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Effect of angiotensin II on follicular atresia in mouse

Cheng Yong, Jiao Lihong, Liu Ruihua, Wang Qingbin, Wang Hong, Xia Guoliang

State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences.Beijing 100080；China

Abstract

The results showed that: (1)a large number of atretic follicles were found in the ovary of 24-day-old mouse after 6-day treatment of PMSG. Deoxyribonucleic acid (DNA) extracted from granulosa cells clearly showed a ladder band under agarose gel electrophoresis analysis. (2)the contents of Ang II in the ovary extremely increased with the development of follicular atresia. (3)Ang II significantly antagonized the stimulating effect of the follicle-stimulating hormone (FSH) on estradiol (E_(2)) generation of granulosa cells. It is suggested that Ang II may be involved in the regulation of follicular atresia in mouse.

Key words: Angiotensin II;Follicular atresia;Granulosa cells;Estradiol

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Citing This Article：

Cheng Yong, Jiao Lihong, Liu Ruihua, Wang Qingbin, Wang Hong, Xia Guoliang. Effect of angiotensin II on follicular atresia in mouse. Acta Physiol Sin 2002; 54 (1): (in Chinese with English abstract).