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Calcitonin gene-related peptide gene therapy suppresses reactive oxygen species in the pancreas and prevents mice from autoimmune diabetes

She Fei, Sun Wei, Mao Jieming, Wang Xian

Institute of Vascular Medicine,Third Hospital,Peking University.Beijing 100083

Abstract

The CGRP gene therapy decreased morbidity of autoimmune diabetes, and significantly ameliorated hyperglycemia in these mice. CGRP gene transfer inhibited the production of ROS and malondialdehyde (MDA). In addition, it enhanced the activity of catalase (CAT) and superoxide dismutase (SOD) significantly. The data suggest that intramuscular CGRP gene transfer ameliorates autoimmune destruction of islet #beta# cells, resulting in significant reduction in diabetes incidence of MLDS diabetes mice. CGRP benefits might be mediated at least in part by inhibiting the oxidative stress in islet #beta# cells of these mice.

Key words: Insulin-dependent diabetes mellitus;Calcitonin gene-related peptide;Gene therapy;Reactive oxygen species

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Citing This Article：

She Fei, Sun Wei, Mao Jieming, Wang Xian. Calcitonin gene-related peptide gene therapy suppresses reactive oxygen species in the pancreas and prevents mice from autoimmune diabetes. Acta Physiol Sin 2003; 55 (6): (in Chinese with English abstract).