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Activating effect of ATP on NO/cGMP pathway in guinea pig cochlea

Zhao Lidong, Li Yingli, Li Ning, Li Xingqi

Institution of Otorhinolaryngology,PLA General Hospital.Beijing 100853；China；Experiment Center,PLA General Hospital.Beijing 100853

Abstract

These results suggest that ATP elevated the concentration of cGMP in cochlear tissue while administration of nonselective nitric oxide synthase inhibitor L-NNA and soluble guanylate cyclase inhibitor ODQ could prevent the increase of cGMP concentration induced by ATP. It is indicated that ATP is involved in the activation of NO/cGMP pathway by elevating Ca~(2+) concentration in the cytoplasm of the cochlea. In turn, NO/cGMP pathway may exert a negative action on the effects of ATP. It is suggested that there is an ATP/Ca~(2+)-NO/cGMP pathway in the guinea pig cochlea. ATP and NO/cGMP pathway jointly regulate the function of the cochlea.

Key words: Guinea pig;Cochlea;ATP;NO/cGMP pathway

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Citing This Article：

Zhao Lidong, Li Yingli, Li Ning, Li Xingqi. Activating effect of ATP on NO/cGMP pathway in guinea pig cochlea. Acta Physiol Sin 2003; 55 (6): (in Chinese with English abstract).