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Effects of agmatine on neuronal discharges in rat hippocampal CA1 area

Wang Zemin, Sun Guangqi, Wang Zhian, He Ruirong

Department of Pysiology,Institute of Basici Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The effects of agmatine (Agm) on the discharges of neurons in CA1 area of hippocampal slices were examined by using extracellular recording technique. These results suggest that agmatine can inhibit the spontaneous discharges and L-glutamate-, Bay K-8644- and L-NAME-induced discharges of hippocampal CA1 neurons. These inhibitory effects of agmatine may be related to the blockade of NMDA receptors anda reduction in calcium influx in hippocampal neurons.

Key words: Agmatine;L-glutamate;Bay;K8644;NG-nitro-L-arginine methyl ester;Hippocampal slices

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Citing This Article：

Wang Zemin, Sun Guangqi, Wang Zhian, He Ruirong. Effects of agmatine on neuronal discharges in rat hippocampal CA1 area. Acta Physiol Sin 2003; 55 (6): (in Chinese with English abstract).