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Electrical activities of bursting-firing neurons in epileptic network reestablishment of rat hippocampus

Wang Wenting, Qin Xingkui, Yin Shijin, Han Dan

Department of Physiology Medical College,Wuhan University.Wuhan 430071,Hubei；China

Abstract

The evoked reactions of the single hippocampal neuron induced by the tetanization mainly included: (1) the firing patterns of the BFNs in ipsilateral anterior dorsal HPC were obviously modulated by the ATPDH from tonic firing into rhythmic bursting. The bursting interspike intervals (BISI) decreased. (2)There were mild modulations of the firing patterns of the BFNs in contralateral anterior dorsal HPC following post-inhibition of the firing rate of single neuron induced by the ATPDH. The interspike intervals (ISI) increased obviously. (3)Post-facilitation of rhythmic bursting-firing of the BFNs in contralateral anterior dorsal HPC was induced by ATADH; both the ISI and the IBI increased. (4) Synchronous or asynchronous rhythmic bursting-firing of the BFNs and the network epileptiform events ipsilateral or contralateral anterion dorsal HPC were elicited by the ATPDH.

Key words: Epileptic network;Bursting-firing neuron;Intersipke interval;Tetanization;Hippocampus

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Citing This Article：

Wang Wenting, Qin Xingkui, Yin Shijin, Han Dan. Electrical activities of bursting-firing neurons in epileptic network reestablishment of rat hippocampus. Acta Physiol Sin 2003; 55 (6): (in Chinese with English abstract).