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Relationship between hippocampal long term potentiation induction and activity of 26S proteasome

Hu Zhian, Tan Yinling, Luo Jun, Li Haidi, Li Xicheng

Department of Physiology,Third Military Medical University.Chongqing 400038；China

Abstract

26S proteasome activity was 190±14.3 cpm/(100#mu#g·2h) before tetanus, a significant increase in 26S proteasome activity 273±18.3 cpm/(100#mu#g·2h) was found 10 min after tetanus, when the slope of fEPSP was markedly increased. Interestingly, 26S proteasome activity returned to baseline level (210±12.8 cpm/(100#mu#g·2h) 60 min after tetanus. Moreover, the N-methyl-D-aspartate (NMDA) receptor inhibitor AP-5, which blocked LTP, prevented the increase in the 26S proteasome activity. The results suggest that NMDA receptors contribute to the transient increase in 26S proteasome activity during induction of LTP in the hippocampal CA1 region.

Key words: Long term;Potentiation proteasome;N-methyl-D-aspartate （ NMDA）;Receptors;Hippocampus;Rats

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Citing This Article：

Hu Zhian, Tan Yinling, Luo Jun, Li Haidi, Li Xicheng. Relationship between hippocampal long term potentiation induction and activity of 26S proteasome. Acta Physiol Sin 2003; 55 (6): (in Chinese with English abstract).