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Role of melatonin in spatial learning and memory in rats and its mechanism

Feng Yin, Zhang Liexiong, Chao Dongman

Department of Neurobiology,Medical Center of Fudan University.Shanghai 200032；China

Abstract

Our results showed that application of melatonin in rats significantly inhibited not only spatial learning and memory, but also LTP in CA1 area. Furthermore, the results indicates that the inhibition of LTP by melatonin may not be mediated by cholinergic system, but may be through the modulation of GABAergic system.

Key words: Melatonin;Spatial learning and memory;Long-term potentiation;Scopolamine;Bicuculline

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Citing This Article：

Feng Yin, Zhang Liexiong, Chao Dongman. Role of melatonin in spatial learning and memory in rats and its mechanism. Acta Physiol Sin 2002; 54 (1): (in Chinese with English abstract).