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The role of MDR1 gene in volume-activated chloride currents in pigmented ciliary epithelial cells

Chen Lixin, Wang Liwei, Jacob T

Laboratory of Cell Biology,Guangdong Medical College.Zhanjiang 524023,Guangdong；China

Abstract

The role of multidrug resistance (MDR1) gene in the activation of volume-activated chloride currents in bovine pigmented ciliary epithelial (PCE) cells was investigated by the patch-clamp technique, the antisense approach, the immunofluorescent technique and the confocal microscopy. The data indicate that the volume-activated chloride current is associated with the endogenous expression of MDR1 gene in PCE cells.

Key words: Epithelial cells;Chloride channels;Oligonucleotides，antisense;Gene expression;Genes;MDR ;

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Citing This Article：

Chen Lixin, Wang Liwei, Jacob T. The role of MDR1 gene in volume-activated chloride currents in pigmented ciliary epithelial cells. Acta Physiol Sin 2002; 54 (1): (in Chinese with English abstract).