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Limb ischemic preconditioning reduces infarct size following myocardialischemia--reperfusion in rats

Dong Jinghui, Liu Yixian, Ji Ensheng, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The results obtained are as follows: (1) During 30 min myocardial ischemia in subsequent 120 min reperfusion, the myocardial infarct size occupied 51.48±0.82% of the area at risk. (2) LIP significantly reduced the myocardial infarct size to 35.14±0.88% (P<0.01), indicating the cardioprotective effect of such an intervention. (3)Femoral nerve section (FNS) completely abolished the cardioprotection afforded by LIP. (4) Intrafemoral artery injection of adenosine (10 nmol/kg) produced a similar effect to that of LIP, reducing the myocardial infarct size to 37.28±1.68%, while intrafemoral vein injection of the same dose of adenosine showed no effect. (5) Pretreatment with a selective adenosine A_(1) receptor antagonist 8-cyclopentyl-1, diproylxanthine (DPCPX) (32 nmol/kg) partially abolished the cardioprotection of LIP on myocardium. Taken together, it is concluded that LIP reduces infarct size following myocardial ischemia-reperfusion, and that the locally released adenosine and thereby the activated relevant neural pathway play an important role in the cardioprotection provided by LIP.

Key words: Ischemia-reperfusion;limb ischemic preconditioning;Adenosine;myocardial infarct size

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Citing This Article：

Dong Jinghui, Liu Yixian, Ji Ensheng, He Ruirong. Limb ischemic preconditioning reduces infarct size following myocardialischemia--reperfusion in rats. Acta Physiol Sin 2004; 56 (1): (in Chinese with English abstract).