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Osteopontin enhances migratory ability of cultured aortic adventitial fibroblasts from spontaneously hypertensive rats

Sun Aijun, Gao Pingjin, Liu Jianjun, Ji Kaida, Zhu Dingliang

Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Second Medical University.Shanghai 200032

Abstract

The results showed that the antisense OPN oligonucleatide significantly inhibited AF migration (cell number per field 38.60±5.98 vs 26.61±3.84, P<0.05), while sense andmismatch OPN oligonucleotide had no effect on cell migration. Therefore, the migration of adventitial fibroblasts appeared to be enhanced in cultures derived from SHR. OPN might be involved in the difference observed.

Key words: aorta;adventitia;Fibroblast;osteopontin;Hypertension;Cell migration;remodeling

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Citing This Article：

Sun Aijun, Gao Pingjin, Liu Jianjun, Ji Kaida, Zhu Dingliang. Osteopontin enhances migratory ability of cultured aortic adventitial fibroblasts from spontaneously hypertensive rats. Acta Physiol Sin 2004; 56 (1): (in Chinese with English abstract).