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Effect of arginine vasopressin on membrane potential of dorsal root ganglion neurons in rats

Hu Haiyan, Sun Zhiping, Zhao Yimei, Si Junqiang, Zheng Yu

Department of Physiology,Shihezi University School of Medicine.Shihezi 832000,Xinjiang；China

Abstract

The results showed that (1) AVP induced hyperpolarization in the membrane of most DRG neurons. (2) The membrane conductance of the DRG neurons increased by 19.32% following application of AVP (P<0.05). (3) Perfusion with balance soldium solution (BSS) containing Cd~(2+) (blocker of Ca~(2+) channel) instead of Na~(+) failed to affect the AVP-induced membrane hyperpolarization of the DRG neurons (P>0.05). After perfusion with BSS containing tetraethylammonium (TEA), however, the extent of AVP-induced hyperpolarization was reduced (P<0.05). (4) The AVP-induced hyperpolarization of the neurons was blocked by the antagonist of AVP V_(1) receptors. The results demonstrate that AVP induces hyperpolarization of most DRG neurons, which might be caused by K~(+) outflow mediated by AVP V_(1) receptors in the membrane of the neurons.

Key words: dorsal root ganglion;intracellar recording;Arginine vasopressin;arginine vasopressin receptor

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Citing This Article：

Hu Haiyan, Sun Zhiping, Zhao Yimei, Si Junqiang, Zheng Yu. Effect of arginine vasopressin on membrane potential of dorsal root ganglion neurons in rats. Acta Physiol Sin 2004; 56 (1): (in Chinese with English abstract).