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Effects of chronic administration of PL017 and beta-funaltrexamine hydrochloride on susceptibility of kainic acid-induced seizures in rats

Liu Hui, Gao Huiming, Zhang Wanqin, Tang Yiyuan, Song Heshan

Department of Neurology,PLA 210 Hospital.Dalian 116021,Liaoning；China；Institute of Neuroinformation,Dalian University of Technology.Dalian 116024,Liaoning

Abstract

There is evidence that 5--7d after acute seizure episodes induced by kainic acid (KA) the rats develop a long-lasting increase in the susceptibility to seizures followed by spontaneous recurrent seizures (SRS). The present study was focused on the role of hippocampal mu opioid receptors (MORs) in the susceptibility of rats to seizures with the KA model of epilepsy. The rats received a convulsant dose of KA (10 mg/kg, i.p.) were continuously infused with a selective MOR agonist PL017 (2.09, 2.59, 3.29 #mu#g/#mu#l), or a selective MOR antagonist #beta#-funaltrexamine hydrochloride (#beta#-FNA, 0.88, 1.10, and 1.35 #mu#g/#mu#l) into ventral hippocampus by means of mini-osmotic pumps. Seven days later, the susceptibility of rats to seizures was checkedby a subconvulsant dose of KA (5mg/kg, i.p.). PL017 infusion shortened the latency and increased the stage of seizures induced by subconvulsant dose of KA in a dose-dependent manner. In contrast, infusion of #beta#-FNA exhibited a dose-dependent effect against seizures challenged by subconvulsant dose of KA. These results indicate that hippocampal MOR may exert a promoting effect on the susceptibility of rats to KA-induced seizures.

Key words: mu型阿片肽受体;癫痫发作敏感性;海马;癫痫;红藻氨酸;大鼠

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Citing This Article：

Liu Hui, Gao Huiming, Zhang Wanqin, Tang Yiyuan, Song Heshan. Effects of chronic administration of PL017 and beta-funaltrexamine hydrochloride on susceptibility of kainic acid-induced seizures in rats. Acta Physiol Sin 2004; 56 (1): (in Chinese with English abstract).