Issue Archive

Muscarinic receptors modulate the mRNA expression of NMDA receptors in brainstem and the release of glutamate in periaqueductal grey during morphine withdrawal in rats

Liu Huifen, Zhou Wenhua, Xie Xiaohu, Cao Junli, Gu Jun, Yang Guodong

Ningbo Instittue of Microcirculation & Henbane, Ningbo Addiction Research and Treatment Center.Ningbo 315010,Zhejiang

Abstract

The results suggest that the expression of NMDA receptors and the release of glutmate in brainstem are involved in the processes of morphine withdrawal and that the NMDA receptor expression is possibly regulated by the muscarinic receptors during morphine whthdrawal.

Key words: morphine dependence;withdrawal symptom;NMDA receptors;nitric oxide synthase;muscannic receptors

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Liu Huifen, Zhou Wenhua, Xie Xiaohu, Cao Junli, Gu Jun, Yang Guodong. Muscarinic receptors modulate the mRNA expression of NMDA receptors in brainstem and the release of glutamate in periaqueductal grey during morphine withdrawal in rats. Acta Physiol Sin 2004; 56 (1): (in Chinese with English abstract).