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Microinjection of neuropeptide Y into periaqueductal grey produces anti-nociception in rats with mononeuropathy

Wang Jiazhen

Department of Physiology,Linyi Medical College.Linyi 276002,Shandong

Abstract

The present study was carried out to investigate the effects of neuropeptide Y (NPY) in the midbrain periaqueductal grey (PAG) on the nociceptive modulation in mononeuropathic rats. NPY was microinjected into the PAG. The latency of paw withdrawal (PWL), assessed by the hot-plate (52℃) and the Randall Selitto test, was measured. Intra-PAG administration of 0.05, 0.1 and 0.2 nmol of NPY significantly increased the PWLs in a dose-dependent manner. Co-administration of 0.2 nmol of NPY_(28-36) and 5.5 nmol of naloxone significantly attenuated the NPY-induced increase in PWLs. The results suggested that Y_(1) receptor may mediate NPY-induced anti-nociception, and that the opioid receptors in PAG may also be involved in this process in mononeuropathic rats.

Key words: 缩爪反应潜伏期;导水管周围灰质;神经肽Y;纳洛酮;伤害性刺激

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Citing This Article：

Wang Jiazhen. Microinjection of neuropeptide Y into periaqueductal grey produces anti-nociception in rats with mononeuropathy. Acta Physiol Sin 2004; 56 (1): (in Chinese with English abstract).