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MK-801 inhibits formalin-induced cyclooxygenase-2 expression in the dorsal horn of the spinal cord in rats

Li Shuqin, Li Wenbin, Sun Xiaocai, Li Qingjun, Chen Xiaoling, Ai Jie

Department of Pathophysiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The results showed that intrathecal injection of MK-801 significantly inhibited the increase of COX-2 expression in the spinal dorsal horn induced by the formalin injection in a dose-dependent manner, suggesting that the activation of NMDA receptor is one of the mechanisms for the formalin-induced increase of COX-2 expression in the spinal dorsal horn.

Key words: cyclooxygenase-2;N-methyl-D-aspartate receptors;MK-801;formalin;spinal cord dorsal horn

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Citing This Article：

Li Shuqin, Li Wenbin, Sun Xiaocai, Li Qingjun, Chen Xiaoling, Ai Jie. MK-801 inhibits formalin-induced cyclooxygenase-2 expression in the dorsal horn of the spinal cord in rats. Acta Physiol Sin 2004; 56 (1): (in Chinese with English abstract).