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NMDA receptors contribute to synaptic transmission in anterior cingulate cortex of adult mice

Liauw J, Wang Guodu, Zhuo Min

Department of Anesthesiology,Anatomy & Neurobiology and Psychiatry,Washington University Pain Center,Washington University, St. Louis, MO63110,USA

Abstract

Here we show that NMDA receptors contribute to synaptic responses in the anterior cingulate cortex (ACC), a region important for cognitive and other brain functions. The contribution of NMDA receptors became more prominent when synapses are stimulated at higher frequencies. Furthermore, at temperatures more close to physiological brain temperatures, more NMDA receptor mediated responses were recorded as compared to the room temperature. These data suggest a new function for NMDA receptors in the ACC as important postsynaptic receptors involved in synaptic transmission, in particular when cells are firing at high frequencies.

Key words: Glutamate;Anterior eingulate cortex;（ACC） pain;Mouse

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Citing This Article：

Liauw J, Wang Guodu, Zhuo Min. NMDA receptors contribute to synaptic transmission in anterior cingulate cortex of adult mice. Acta Physiol Sin 2003; 55 (4): (in Chinese with English abstract).