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Changes in glycine content in mouse brain during hypoxic preconditioning

Liu Hongyan, Lu Guowei, Wang Weizhong

Department of Pharmacology,Bethune Medical University.Changchun 130021,Jilin；China

Abstract

Glycine content of the whole btain and subregions was measured by high pressure liquid chromatography (HPLC) in mice during their repetitive exposures to hypoxia. The content sof glycine in whole brain, diencephalon, and hippocampus and brain stem was significantly increased as the animals^ tolerance to hypoxia was increased. The results suggest that glycine, as an inhibitory neurotransmitter in the brain, may positively contribute to the development of hypoxic preconditioning.

Key words: Glycine;Hypoxic tolerance;Hypoxic preconditioning

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Citing This Article：

Liu Hongyan, Lu Guowei, Wang Weizhong. Changes in glycine content in mouse brain during hypoxic preconditioning. Acta Physiol Sin 2001; 53 (6): (in Chinese with English abstract).