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Identification of genes related to cell phenotypic transition by differential display analysis

Sun Aijun, Gao Pingjin, Liu Jianjun, Ji Kaida, Zhu Dingliang

Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Second Medical University.Shanghai 200025

Abstract

This study suggests that the downregulation of gene encoding NADH dehydrogenase subunit 5 and upregulation of osteopontin gene and several other unknown genes may be involved in the phenotypic transition of adventitial fibroblasts to myofibroblats. Inhibition of the expression of OPN may play an important role in the process of vascular remodeling.

Key words: Adventitia;Fibroblasts;Myofibroblasts;Differential display PCR antisense ;

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Citing This Article：

Sun Aijun, Gao Pingjin, Liu Jianjun, Ji Kaida, Zhu Dingliang. Identification of genes related to cell phenotypic transition by differential display analysis. Acta Physiol Sin 2001; 53 (6): (in Chinese with English abstract).