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Effect of interleukin-2 on intracellular calcium transients in rat ventricular myocytes

Cao Chunmei, Xia Qiang, Ye Zhiguo, Zhang Xiong

Department of Physiology,Zhejiang University School of Medicine.Hangzhou 310031,Zhejiang

Abstract

It is concluded that the depressant effect of IL-2 on the [Ca~(2+)]_(i) transients of isolated ventricular myocytes is mainly mediated by cardiac #kappa# opioid receptor pathway including a PTX sensitive Gi-protein and PLC, but not by tyrosine kinase.

Key words: Interleukiir 2;Opioid receptors;Intracellular calcium;Gi-protein;Phospholipase C

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Citing This Article：

Cao Chunmei, Xia Qiang, Ye Zhiguo, Zhang Xiong. Effect of interleukin-2 on intracellular calcium transients in rat ventricular myocytes. Acta Physiol Sin 2001; 53 (6): (in Chinese with English abstract).