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Correlation between mitochondrial membrane potential and neurotoxic effect of corticosterone on primary cultured hippocampai cells

Nie Wei, Zhang Yongxiang, Zhou Jinhuang

Beijing Institute of Pharmacology and Toxicology.Beijing 100850

Abstract

It is suggested that hippocampal neurons are more sensitive to the toxic effect of CORT in comparision with astrocytes. Neurotoxic effect of CORT can be reduced by high concentration of glucose. CORT-induced reduction of MMP may be one of th emechanisms for its neurotoxicity.

Key words: Corticosterone;Hippocampus;Mitochondrial membrane potential

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Citing This Article：

Nie Wei, Zhang Yongxiang, Zhou Jinhuang. Correlation between mitochondrial membrane potential and neurotoxic effect of corticosterone on primary cultured hippocampai cells. Acta Physiol Sin 2001; 53 (6): (in Chinese with English abstract).