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Down-regulation of ET_(A) receptor of vascular smooth muscle cells by 17#beta#-estradiol

Wang Tinghuai, Tan Zhi, Liu Peiqing, Lu Wei, Yang Dan, Pan Jingyun

Department of Physiology,Sun Yat-sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

The results demonstrate that proliferation of VSMCs stimulated by ET-1 was mainly mediated through ET_(A) receptor. Due to the down-regulation of ET_(A) receptor and mediation of estrogen receptor, 17#beta#-estradiol inhibits the ET-1-induced proliferation of VSMCs and decreases the vascular reactivity of ovariectomized rats.

Key words: Estrogen;Estrogen receptor;VSMCs;Endothelin;Endothelin receptor

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Citing This Article：

Wang Tinghuai, Tan Zhi, Liu Peiqing, Lu Wei, Yang Dan, Pan Jingyun. Down-regulation of ET_(A) receptor of vascular smooth muscle cells by 17#beta#-estradiol. Acta Physiol Sin 2001; 53 (5): (in Chinese with English abstract).