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Inhibition of PKC and ERK1/2 in cultured rat vascular smooth muscle cells by angiotensin-(1-7)

Zhong Jian, Zhu Zhiming, Yang Yongjian

Department of Hypertension and Endocrinology and Chongqing Institute of Hypertension,Daping Hospital,The Third Military Medical University.Chongqing 400042

Abstract

Ang II increased VSMC DNA and protein synthesis, and promoted protein expression of PKC-#zeta# and ERK1/2. In contrast, Ang-(1-7) not only inhibited PKC-#zeta# and ERK1/2 protein content, but also decreased Ang II mediated VSMC hyperplasia, as compared with the controls (P<0.01 or P<0.05).

Key words: Angiotensirr(1-7);Protein kinase C;Extracellular regulated protein kinases;Vascular smooth muscle cells

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Citing This Article：

Zhong Jian, Zhu Zhiming, Yang Yongjian. Inhibition of PKC and ERK1/2 in cultured rat vascular smooth muscle cells by angiotensin-(1-7). Acta Physiol Sin 2001; 53 (5): (in Chinese with English abstract).