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Effects of Bay K8644 and nifedipine on L-type Ca~(2+) channels in hypothalamic neurons of rats

Fu Qingjie, Zou Fei

Department of Thermal Environment Medicine,First Military Medical University.Guangzhou 510515,Guangdong

Abstract

To investigate the effects of Bay K8644 and nifedipine on L-type of Ca~(2+) channels in hypothalamic neurons, the cell-attached patch-clamp technique was used to record Ca~(2+) current from isolated neurons. The results showed that the averaged open time and NPo markedly increased by Bay K8644, but had no effect on channel conductance. Nifedipine, on the contrary, had an inhibitory effect on the L-type Ca~(2+) channels.

Key words: Hypothalamus;Ltype Cat~(2+) channel;Bay K8644;Nifedipine;Patch-clamp technique

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Citing This Article：

Fu Qingjie, Zou Fei. Effects of Bay K8644 and nifedipine on L-type Ca~(2+) channels in hypothalamic neurons of rats. Acta Physiol Sin 2001; 53 (5): (in Chinese with English abstract).