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Relationship between dopamine and iron contents in the brain of Parkinsonian rats

Jiang Hong, Chen Wenfang, Xie Junxia

Medical School of Qingdao University.Qingdao 266021,Shandong

Abstract

The results strongly suggest that 6-OHDA reduces the DA release from CPu, in which iron plays an important role. Elevation of iron content in SN is one of the mechanisms responsible for the reduction of DA content. Desferrioxamine mesylate may exert a protective action on dopaminergic neurons.

Key words: Parkinsonian rats;Iron;Desferrioxamine mesylate;Substantia nigra;Caudate putamen;Dopamine

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Citing This Article：

Jiang Hong, Chen Wenfang, Xie Junxia. Relationship between dopamine and iron contents in the brain of Parkinsonian rats. Acta Physiol Sin 2001; 53 (5): (in Chinese with English abstract).