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Desensitization of adrenomedullin and calcitonin gene-related peptide receptors in vascular smooth muscle cells--Effects of receptor activity-modifying protein

Qi Yongfen, Xue Lin, Chai Sanbao, Shi Yanrong, Pang Yongzheng, Tang Chaoshu

Institute of Cardiovascular Research,The First Hospital,Peking University.Beijing 100034

Abstract

Results indicate that ADM receptors do not desensitize in VSMCs in contrast to CGRP-receptors, which are desensitized by pre-exposure to ADM or CGRP. These data also suggest that the desensitization phenomenon of ADM is different from that of CGRP.

Key words: Adre nome dullin;Calcitonin gene-related peptide;Vascular smooth muscle cells;Densensitization;Receptor activity modifying protein

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Citing This Article：

Qi Yongfen, Xue Lin, Chai Sanbao, Shi Yanrong, Pang Yongzheng, Tang Chaoshu. Desensitization of adrenomedullin and calcitonin gene-related peptide receptors in vascular smooth muscle cells--Effects of receptor activity-modifying protein. Acta Physiol Sin 2001; 53 (5): (in Chinese with English abstract).