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Changes in cyclin expression during proliferation and differentiation of CD34~(+) cells derived from fetal liver induced by thrombopoietin

Ma Dongchu, Jin Boquan, Sun Yinghui, Chang Kuizhong, Dai Bing, Chu Junjie, Liu Yage

Northern Hospital.Shenyang 110015,Liaoning；China

Abstract

These data suggest that (1) TPO induced proliferation and differentiation of FL derived CD34~(+) cells through upregulation of cyclin B1 in G2+M phases and cyclins D1 and D3 in all phases of cell cycle, and (2) Continuing high level of cyclin B1 and decreases of cyclins D1 and cyclin D3 on MKs in G2+M phases may contribute to a retardation of MK endoreduplication.

Key words: Cyclins;Thrombopoietin;CD3~(4+)cells;Megakaiyocyte

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Citing This Article：

Ma Dongchu, Jin Boquan, Sun Yinghui, Chang Kuizhong, Dai Bing, Chu Junjie, Liu Yage. Changes in cyclin expression during proliferation and differentiation of CD34~(+) cells derived from fetal liver induced by thrombopoietin. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).