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Hemorrhagic shock induces changes in large-conductance Ca~(2+)-dependent K~(+) channel activity in mesenteric arterial smooth muscle cells of rats

Kai Li, Hu Deyao, Wang Zhongfeng, Shi Yuliang, Liu Liangming

Research Institute of Surgery,Daping Hospital,Third Military Medical University.Chongqing 400042；China

Abstract

The results showed that the BK_(Ca) activity was inhibited with decreased open probability (P_(o)) and single-channel conductance. The decrease of P_(o) resulted from an increase of the close time constant (#tau#_(cs)) in the compensatory stage of HS, i.e. the term of hyperresponse of the muscle to norepinephrine (NE) (HS lasted for about 40 min). During the decompensation stage of HS, i.e. the period of hyporesponse to NE (HS developed for 3 h), the BK_(Ca) activity was enhanced with the increase in single-channel conductance and P_(o) which was a result of a decrease in #tau#_(cs).

Key words: Hemorrhagic shock;Vascular response to norepinephrine;Large-conductance calcium-activated potassium channel;Vascular smooth muscle cell;Mesenteric artery

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Citing This Article：

Kai Li, Hu Deyao, Wang Zhongfeng, Shi Yuliang, Liu Liangming. Hemorrhagic shock induces changes in large-conductance Ca~(2+)-dependent K~(+) channel activity in mesenteric arterial smooth muscle cells of rats. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).