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Vasonatrin peptide attenuates hypoxia-induced increase in [Ca~(2+)]_(i) of cultured rat cardiac fibroblasts

Guo Haitao, Zhu Miaozhang, Lu Shunyan, Yu Jun, Dong Mingqing, Gao Zhao, Shi Putao

Department of Physiology,Fourth Military Medical University.Xi^an 710032,Shaanxi；China

Abstract

It was found that hypoxia (2%-3%) increased significantly the MTT optical density (OD) of cardiac fibroblasts (P<0.05 vs control group), but the increase was greatly attenuated in the VNP (10~(-6)mol/L) group and also the incorporation of ~(3)H-TdR in cardiac fibroblasts (P<0.05 vs hypoxia group). VNP (10~(-6)mol/L) also decreased the intracellular level of Ca~(2+) which was increased by hypoxia (P<0.05) as compared with control and hypoxia group.

Key words: Vasonatrin peptide;Hypoxia;Cardiac fibroblasts;Ca~(2+)

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Citing This Article：

Guo Haitao, Zhu Miaozhang, Lu Shunyan, Yu Jun, Dong Mingqing, Gao Zhao, Shi Putao. Vasonatrin peptide attenuates hypoxia-induced increase in [Ca~(2+)]_(i) of cultured rat cardiac fibroblasts. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).