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Inositol 1, 4, 5-triphosphate receptors (IP_(3)Rs) in myocardial nuclei involved in pressure overload-induced hypertrophy of rat heart

Liu Jian, He Zuoyun, Xu Shumin, Liu Fuyu, Wang Peiyong

Department of Cardiology,Xinqiao Hospital,Third Medical University.Chongqing 400037；China

Abstract

The results suggest that IP_(3)Rs exist in myocardial nuclei and are down regulated by CaM, PMA and free Ca~(2+). The increase of the binding sites of IP_(3)Rs in the nuclear envelopes and the decrease of their affinity might play importment roles in the development of overload induction of cardiac hypertrophy.

Key words: Myocardial hypertrophy;Cell nucleus;Inositol 1 ,4 ,5-triphosphate receptors

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Citing This Article：

Liu Jian, He Zuoyun, Xu Shumin, Liu Fuyu, Wang Peiyong. Inositol 1, 4, 5-triphosphate receptors (IP_(3)Rs) in myocardial nuclei involved in pressure overload-induced hypertrophy of rat heart. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).