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Increase in amount and affinity of adenosine receptor in rat hippocampal cellular membranes induced by cerebral ischemic preconditioning and its protective effects on the neurons

Zhou Aimin, Li Qingjun, Chen Xiaoling, Li Wenbin

Department of Pathophysiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The results showed that cerebral ischemic preconditioning increased the amount and affinity of ADO receptor in hippocampal cellular membranes, and resisted the down-regulating of ADO receptor caused by severe ischemia, suggesting an important role of the increase in amount and affinity of ADO receptor in the induction of brain ischemic tolerance.

Key words: Ischemia;Ischemic preconditioning;Adenosine;Adenosine receptor;Hippoca mpus;Brain

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Citing This Article：

Zhou Aimin, Li Qingjun, Chen Xiaoling, Li Wenbin. Increase in amount and affinity of adenosine receptor in rat hippocampal cellular membranes induced by cerebral ischemic preconditioning and its protective effects on the neurons. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).