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Suppression of glutamate neurotoxicity by 5-HT in hippocampal neurons

Ma Qiang, Liu Wei, Wu Liying, Chao Fuhuan

Institute of Health and Environmental Medicine.Tianjin 300050；China；Institute of Basic Medicine,Academy of Military Medical Sciences.Beijing 100850

Abstract

The effects of excess glutamate on the survival rate of cultured hippocampal neurons, the population spike (PS) of CA1 area of hippocampal slices and the Ca~(2+) current of hippocampal neurons were observed in rats. Decreased survival rate of hippocampal neurons in the presence of excess glutamate was partially reversed by 5-HT, which was in association with a less decrease of PS magnitudes. The Ca~(2+) inward current induced by glutamate was significantly diminished in the presence of 5-HT.

Key words: Serotonin(5-HT);Glutamate(an);Hippocampal neuron;Stress

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Citing This Article：

Ma Qiang, Liu Wei, Wu Liying, Chao Fuhuan. Suppression of glutamate neurotoxicity by 5-HT in hippocampal neurons. Acta Physiol Sin 2001; 53 (4): (in Chinese with English abstract).