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Characteristics of #alpha#_(2)-adrenoceptor mediated contractile response in isolated aortae of rats

Lu Zhizhen, Zhang Youyi, Dong Erdan, Han Qide

Institute of Vascular Medicine,Third Hospital,Peking University.Beijing 100083

Abstract

It was found that both #alpha#_(1) and #alpha#_(2)-AR (mainly #alpha#_(1)-AR) mediated the contractile response. While #alpha#_(1)-AR enhanced the contractile response mediated by #alpha#_(2)-AR, #alpha#_(2)-AR had no effect on that mediated by #alpha#_(1)-AR. When #alpha#_(1)-AR was irreversibly blocked and the activity of #alpha#_(2)-AR remained intact, the contractile response mediated by #alpha#_(2)-AR was no longer observed. The contractile response only reappeared in the presence of KCl of the threshold level, and the extent of the maximum contraction decreased, compared with control (with #alpha#_(1)-AR being intract). The results show that there exists a functional #alpha#_(2)-AR in rat aorta, however, the contractile effect of which depends on the stimulation of #alpha#_(1)-AR.

Key words: Aortae;Receptor;Adrenaline

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Citing This Article：

Lu Zhizhen, Zhang Youyi, Dong Erdan, Han Qide. Characteristics of #alpha#_(2)-adrenoceptor mediated contractile response in isolated aortae of rats. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).