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Inhibitory effects of melatonin on the development of 17-#beta#-estradiol induced prolactinoma in relation to plasma prolactin and peroxidative lipid contents

Gao Lie, Xu Jianping, Shan Huimin, Zhang Rong, Xu Rongkun

Department of Physiology,Institute of Basic Medical Sciences,Peking Union Medical College and Chinese Academy of Medical Sciences.Beijing 100005；China

Abstract

The experiments demonstrate that the inhibition of the development of E_(2)-induced prolactinoma by adequate dosage of melatonin may be related to the inhibitory effects of MLT on the secretion of PRL, but not to the antioxidative action of MLT.

Key words: Melatonin;17-#bet#-estradiol;Prolactinoma;Antitumorigenesis;Prolactin

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Citing This Article：

Gao Lie, Xu Jianping, Shan Huimin, Zhang Rong, Xu Rongkun. Inhibitory effects of melatonin on the development of 17-#beta#-estradiol induced prolactinoma in relation to plasma prolactin and peroxidative lipid contents. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).