Issue Archive

Characteristic behavioral seizures and abnormal signal asymmetry of magnetic resonance imaging in an electrogenic rat model of chronic epilepsy

Han Dan, Zhang Xianrong, Tang Yuefeng, Liu Maili, Yin Shijin

Department of Physiology,Medical College,Wuhan University.Wuhan 430071,Hubei；China

Abstract

Chronic tetani (60 Hz, 2 s, 0.4-0.6 mA) were administered to the dorsal hippocampus (DHPC) or the medial temporal lobe neocortex (MTNC) of rats, to study the role of the entorhinal cortex (EC)-hippocampal loop in temporal lobe epileptogenesis. This was repeated once a day for 7 or 10 days. Magnification of hyper-intensity was induced by tetanization of the HPC or the MTNC, as detected by contralateral T_(2) weighted magnetic resonance imaging (T_(2)-WI). The effects were associated with an enlarged volume of the lateral ventricle (LV), which was verified histologically.

Key words: Asymmetry;T_(2)-weighted magnetic resonance imaging;Primary wet dog shakes;Hippocampus;Medial temporal neocortext;Rats

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Han Dan, Zhang Xianrong, Tang Yuefeng, Liu Maili, Yin Shijin. Characteristic behavioral seizures and abnormal signal asymmetry of magnetic resonance imaging in an electrogenic rat model of chronic epilepsy. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).