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Suppression of large conductance Ca~(2+)-activated K~(+) channels by amyloid #beta#-protein fragment 31-35 in membrane patches excised from hippocampal neurons

Qi Jinshun, Qiao Jiantian

Department of Neurobiology,Shanxi Medical University.Taiyuan 030001,Shanxi

Abstract

To clarify the shortest essential active sequence in amyloid #beta#-protein (A#beta#P) responsible for affecting neuronal electrophysiological properties, the efffects of fragments 31-35 and 25-35 of A#beta#P on the arge conductance Ca~(2+)-activated potassium (BK) channels were investigated in the "inside-out" membrane patches excised from hippocampal neurons of rats.

Key words: Amyloid #beta#-protein;Fragment 31-35;Fragment 25-35;BK channel;Hippocampal neuron;Membrane patch

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Citing This Article：

Qi Jinshun, Qiao Jiantian. Suppression of large conductance Ca~(2+)-activated K~(+) channels by amyloid #beta#-protein fragment 31-35 in membrane patches excised from hippocampal neurons. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).