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Effect of estrogen on dopamine release evoked by electric stimulation of central amygdaloid nucleus

Xie Junxia, Liu Bin

Department of Physiology,Medical College of Qingdao University.Qingdao 266021,Shandong

Abstract

In vivo fast cyclic voltammetry (FCV) was used to investigate dopamine (DA) release from central amygdaloid nucleus (CAN) of ovariectomized (OVX), estrogen-treated and normal female rats. Radioimmunoassay was used to measure the serum concentration of estradiol (E_(2)). DA release was significantly higher in OVX rats treated with estradiol benzoate (EB) as compared with controls. The DA release due to electric stimulation is dose-dependent on serum concentration of estradiol, suggesting that estrogen may play an important role in regulating DA release from CAN.

Key words: Estrogen;Dopamine;Central amygdaloid nucleus;Rats;Fast cyclic volternmetry

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Citing This Article：

Xie Junxia, Liu Bin. Effect of estrogen on dopamine release evoked by electric stimulation of central amygdaloid nucleus. Acta Physiol Sin 2001; 53 (3): (in Chinese with English abstract).