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Inhibitory effect of aminoglycoside antibiotics on rabbit carotid baroreceptor activity in vitro

Liu Dongxia, Niu Weizhen, Shen Jing

Department of Cardiovascular Physiology,Capital University of Medical Sciences.Beijing 100054

Abstract

These resutls suggest: (1)aminoglycoside antibiotics can inhibit CS-BRA specifically thus providing a new tool for the study of baroreceptors; (2) calcium ions are not necessary for producing generator potentials of baroreceptors, and the L-type calcium channel does not seem to be involved in CS-BRA per se; and (3) the inhibitory effects of aminoglycoside antibiotics on CS-BRA may not be related to the blocking of L-type calcium channels.

Key words: Baroreceptor;Aminoglycoside antibiotics;Calcium;Antagonists of L-type calcium channel

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Citing This Article：

Liu Dongxia, Niu Weizhen, Shen Jing. Inhibitory effect of aminoglycoside antibiotics on rabbit carotid baroreceptor activity in vitro. Acta Physiol Sin 2001; 53 (2): (in Chinese with English abstract).